Role of P-glycoprotein in the pharmacotherapy of pregnant women

Role of P-glycoprotein in the pharmacotherapy of pregnant women

Blog Article

This review addresses the function of the protein-transporter glycoprotein-P (Pgp, tokidoki hello kitty blind box ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals.We discuss the relationship between the transporter function and the hormone fluctuations during pregnancy.We cite studies on the association between the MDR1/mdr1 gene polymorphisms and the hemato-placental barrier permeability for Pgp substrates, as well as fetal malformations.Under a separate section, drugs commonly stuart products emcelle tocopherol used in pregnant women are characterized in terms of their roles as substrates, inducers or inhibitors of the Pgp transporter.